Acta Medica Medianae
INFLUENCE OF HIGH CORTISOL DOSES UPON THE SERUM IMMUNOGLOBULIN LEVEL
Zoran PAVLOVIĆ and Voja PAVLOVIĆ
Clinic for Hematology and Immunology of the Clinic Center, Niš
The effects of cortisol upon the serum immunoglobulin concentration are examined. The experiment involved male guinea pigs of the body weight from 300 to 400 g that were normally fed and lived under the common laboratory conditions. The guinea pigs were divided into an experimental and a control group. The experimental group's guinea pigs were given every day (in a 6 days' period) a subcutaneous dose of 80 g of cortisol/kg/per day, while the control group ones were given only one ml of the physiological solution. Two weeks after the last received dose of cortisol or physiological solution the cordial puncture was applied to take a blood sample in which the level of the serum IgA, IgG and IgM was determined. In the experimental group animals the serum IgG value was 11,2 mg/ml at the beginning and 8,7 mg/ml at the end of the experiment (reduction for 22,1%), while the TgA concentration at the end of the experiment was reduced for 5,8%, while the IgM concentration for 12,9%. The serum immunoglobulin concentration in the control group guinea pigs does not reveal any significant differences at the beginning and the end of the experiment.
Key words: Cortisol, high doses, serum immunoglobulins