Acta Medica Medianae
EFFECTS OF A SHORT INSULIN THERAPV UPON THE NSULIN SECRETION FUNCTION IN THE PATIENTS SUFFERING FROM TYPE 2 DIABETES
Milica Pešić, Slobodan Antić, Dragan Dimić, Saša Živić and Saša Radenković
Clinic for Endocrinology, Diabetes and Metabolism Diseases of the Clinic Center, Nis
The classic understanding of the insulin secretion defect and the insulin resistance in the type 2 diabetes has been completed by the findings about the important role of hyperglycemia in additional damaging of the insulin secretion function and strengthening post-receptor defects in the insulin activity - this effect is known as glucose toxicity. On the basis of these findings an interest appeared in applying short insulin therapy in the type 2 diabetes whose aim is the correction of glycemia and elimination of the glucose toxicity effects. The examination comprised 35 patients of type 2 diabetes who were subdued, for four weeks, to diverse regimes of the insulin therapy. The results clearly show that the insulin therapy does not only lead to the correction of glycemia but also to the correction of the insulin secretion function and reduction of the insulin resistance with these patients. The regime of the intensified insulin therapy shows a higher efficiency with respect to the regime with two daily insulin doses.
Key words: Type 2 diabetes, insulin secretion function, insulin resistance, glucose toxicity, insulin therapy