Acta Medica Medianae
CHANGE OF THE ENZYME SDH ACTIVITY IN THE LIVER
AND OF THE BIOCHEMICAL PARAMETERS IN THE BLOOD
OF THE RATS TREATED WITH GENTAMICIN
Nenad Stojiljković, Dragoljub Jovanović, Mirjana Radenković, Slavimir Veljković, Milan Ćirić, and Dragan Radovanović
Instifute for Physiology of the Faculty of Medicne, Niš
The change ofthe enzyme SDH activity in the liver as well as the change of the biochemical parameters (sGOT, sGPT and bilirubins) in the blood of the rats treated with gentamicin. In the experimental group of animals treated with gentamicin (100 mg/kg TT/24 h) for eight days it was found that the highest SDH activity was in the perivenular zone of the acinus (+++), that the enzyme's reduced activity was in the intermediary zone (+) and that the SDH activity in the perportal zone of the acinus was just in traces (+). In the control group of animals treated with the physiological solution (1 ml/kg TT/24 h), the enzyme SDH activity was the most prominent in the perivenular zone of the acinus (+++), while in the intermediary and the periportal zone the enzyme's activity was preserved but somewhat weaker (++). The results of the comparative study ofenzymohistochemical and biochemical changes confirm the existence of an important correlation betwen the gentamicin application and the observed changes.