|Editorial  board | About the Journal   | Instructions for Authors | Peer Review Policy | Clinical and Experimental Work Code |   Contact  |   


Acta Medica Medianae
Vol. 42
Number 1, Januar, 2003
UDK 61
YU ISSN 0365-4478


Institut za patološku fiziologiju, Medicinski fakultet
Brace Taskovic 81, 18000 Niš, Srbija i Crna Gora
Tel.: 018/326-644,


The frequency and association of risk factors in development of coronary heart disease in diabetes mellitus

Boris Đinđić, Stojan Radić, Goran Damnjanovic*, Todorka Savić, Slobodan Antić** i Dušan Sokolović


Institut za patološku fiziologiju Medicinskog fakulteta
Interno odeljenje Vojne bolnice u Nišu*
Klinika za endokrinologiju, dijabetes i bolesti metabolizma
Kliničkog centra u Nišu**

The coronary heart disease (CHD) is a leading cause of lethality in both sexes. The risk for development of CHD is 2-4 times higher in non insulin dependent diabetes mellitus (NIDDM) than in nondiabetics, and annual rate of fatal and non-fatal cardiovascular diseases in NIDDM is 2-5%. The etiology of CHD is still unknown until the risk factors connected to the development of CHD are well known. The purpose of this research was to establish the frequency and importance of the risk factors in development of CHD in NIDDM. The research included 60 patients with NIDDM who were by presence of CHD classified into two groups. We determined body mass index and waist hip ratio, total and HDL cholesterol, triglicerides, LDL cholesterols, uric acid and fibrinogen. Values of BMI were statistically higher in patients with CHD than in diabetics without CHD 29.67+3.31 vs. 27.873.17 kg/m2 (p<0.05). Raised risk levels of cholesterol had 90% with CHD and 76% without CHD (Hi2=6.12, p<0.05). Larger percentage of patients in group with CHD had raised lipid risk levels of triglicerides 70% than in patients without CHD 56.5% (Hi2=4.36, p<0.05). The obesity was relatively rare in patients without CHD than in diabetics with CHD (13.6% vs. 76%, p<0.01). The frequency of risk factors was very high in NIDDM patients, which clearly points at their cumulative effect in development of CHD in diabetics. Acta Medica Medianae 2003; 42(1):21-26.

Key words: diabetes, risc factors, coronary heart disease