No 2, April, 2003
YU ISSN 0365-4478
Klinika za zarazne bolesti Kliničkog centra,
Braće Tasković 48 18000 Niš,
Srbija i Crna Gora
APPROACH TO THE PATIENTS SUFFERING FROM CHRONIC HEPATITIS C
Ljiljana Konstantinović i
Klinika za zarazne bolesti Kliničkog centra u Nišu
The examination comprised a total number of 16 persons suffering from HCV
infection that was confirmed by the clinic, biochemical and pathohistological
method. The examined patients were divided into two groups, one group comprising
11 while the other comprising 5 patients. The patients of the first group were
treated with recombinant interferon (dose of 3 x 3 MU) while the patients of the
second group were treated with the combination of interferon (3 x 3 MU) and
ribavirin (1000 : 1200 per day).
The treatment lasted 6 to 12 months; the values of alanine aminotransferase
(ALT), pathohistological changes and behavior of the HCV-RNA titer were followed
in that period of time.
During the treatment the effect of the side effect, of the "flu like" type was
followed at the same time as well as other late manifestations.
A more favorable effect of the treatment was registered in the 2nd group of the
patients who had a less frequent occurrence of the biochemical relapse and a
more frequent drop of the HCV-RNA titer.
However, statistical relevance was not determined since the examination was done
on a rather smaller number of the patients. Acta Medica Medianae 2003; 42 (2):
Key words: HCV, Interferon, Ribavirin, ALT, HCV-RNA