Number 3, Juli, 2003
YU ISSN 0365-4478
Medicinski fakultet S. Markovića 69,
Srbija i Crna Gora
FAMILIAL AGGREGATION OF
Medical faculty, Kragujevac
The aim of this study was to investigate possible association between heredity
and bladder cancer occurrence in our population.
Analitical method was used, and investigation was conducted as case-control
study. The study group was composed of 130 consecutive bladder cancer patients
and the same number of controls individually matched to patients by sex, age (±
2 years) and place of residence (rural, urban).
For genealogical analysis, both cases and controls were requested to list all
their 1st and 2nd degree blood related relatives along with their health status.
Family trees were drawn for each of the subjects. The presence of bladder
cancer, bladder benign tumors and any other malignant tumors in relatives were
recorded. According to our results cases had bigger number of the second degree
relatives than controls (t=2.308; p=0.023). There was no significant difference
in frequency of bladder tumours between the first and second degree relatives of
case and control group. According to Wilcoxon test, number of second degree
related relatives diseased of malignancy (without bladder tumours) in case
group, was in positive corelation with bladder cancer occurrence (Z=2.559;
p=0.010). Acta Medica Medianae 2003; 42(3):19-21.
Key words: bladder cancer, case-control study, familial aggregation