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Acta Medica Medianae
Vol. 46, No 3, Oktobar, 2005
UDK 61
YU ISSN 0365-4478





Miodrag Radović
Klinika za ginekologiju i akušerstvo Kliničkog centra
Bulevar dr Zorana Đinđića 48
18000 Niš, Srbija i Crna Gora



ovarian arrHenoblastoma – Case report

Miodrag Radović1, Radomir Živadinović1, Tomislav Jocić2, Ivana Stojanović3, Miljan Krstić3 i Vuka Katić3

Klinika za ginekologiju i akušerstvo Kliničkog centra u Nišu1
Odeljenje za patologiju Medicinskog centra u Pirotu2
Institut za patologiju Kliničkog centra u Nišu3



Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign and almost all are localized unilaterally. Herewith, we describe an ovarian Sertoli- Leydig cell tumor (arrhenoblastoma) with virilization, in an 63-year-old woman. A left salpingo-oohorectomy (and hysterectomy) was performed. Macroscopically, the tumor was 10 x 8 x 6cm, incapsulated, yellow-white in color, both solid and pseudocystic. Microscopically, the tumor was well differentiated, composed from Sertoli-Leydig cells, mixed with theca cells, fibrocytes and collagen fibers. During the 4-year follow-up, there was neither clinical nor sonographical evidence of recurrence. The treatment of this pathological entity has to be individualized according to the patient’s age, stage the of tumor and degree of differentiation. Acta Medica Medianae 2005; 44 (3); 59 – 61.

Key words: ovarian arrhenoblastoma, clinical characteristics, morphological characteristics