Acta Medica Medianae
NATURAL AND PARTIALLY SYNTETIc ANALGESIcS
Jasmina Tomin1, Zoran Bojanic1, Jelena Zivkovic1, Stefan Bogosavljevic1, Vladmila Bojanic1, Jelena Zivanov-Curlis1 and Stevan Glogovac2
Faculty of Medecine, Nis1 .
Humans have a
long hystory of stimulating and mind-altering substances use.
Depressive drugs, including morphine and other narcotics,
barbiturates and ethanol, are strongly addictive for susceptible
individuals. The phenomenon is most striking in the case of opiates.
Morphine is an alkaloid of opium. Named after the Roman god of
dreams, Morpheus, the compound has potent analgesic properties
toward all types of pain. By supstitution of two hydroxylic groups
of morphine many natural and semysyntetic derivatives with different
pharmacological activity and analgesic action are obtained.
Determinations and quantifications of narcotic analgesics in drug
addicts are important in forensic medicine and clinical toxicology.
With development of highly sensitive chromatography technique
(HPLC-GC, GH-MS), more and more substances are determined, including
opioid drugs: morphine, codeine, dyhydrocodeine, and heroin and
6-monoacetyl morphine. Hair analysys by HPLC/MS spectroscopy is an
effective forensic tool for determining the use of abused drugs. The
“fingerprint” for heroin in the mixture with the other substances