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Acta Medica Medianae
Vol. 46, No 4, December, 2005
UDK 61
YU ISSN 0365-4478





Jasmina Tomin
Department of Pharmacy, Faculty of Medicine
81 Dr Zoran Djindjic Street
18000 Nis, Serbia and Montenegro
Phone: 018/ 226 712, 018/ 531864




Jasmina Tomin1, Zoran Bojanic1, Jelena Zivkovic1, Stefan Bogosavljevic1, Vladmila Bojanic1, Jelena Zivanov-Curlis1 and Stevan Glogovac2


Faculty of Medecine, Nis1 .
Clinical Center, Leskovac2 .



Humans have a long hystory of stimulating and mind-altering substances use. Depressive drugs, including morphine and other narcotics, barbiturates and ethanol, are strongly addictive for susceptible individuals. The phenomenon is most striking in the case of opiates. Morphine is an alkaloid of opium. Named after the Roman god of dreams, Morpheus, the compound has potent analgesic properties toward all types of pain. By supstitution of two hydroxylic groups of morphine many natural and semysyntetic derivatives with different pharmacological activity and analgesic action are obtained. Determinations and quantifications of narcotic analgesics in drug addicts are important in forensic medicine and clinical toxicology. With development of highly sensitive chromatography technique (HPLC-GC, GH-MS), more and more substances are determined, including opioid drugs: morphine, codeine, dyhydrocodeine, and heroin and 6-monoacetyl morphine. Hair analysys by HPLC/MS spectroscopy is an effective forensic tool for determining the use of abused drugs. The “fingerprint” for heroin in the mixture with the other substances
(1-10 components) is determined by 1D-TOCSY NMR. Acta Medica Medianae 2005;44(4): 67 – 73.

Key words: antitussive agents, codeine, heroin, morphine, opioid analgesics