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Acta Medica Medianae
Vol. 46, No 4, December, 2005
UDK 61
YU ISSN 0365-4478





Nenad Ponorac
Katedra za fiziologiju Medicinskog fakulteta.
Save Mrkalja 14
78000 Banjaluka
Republika srpska
Tel.: +387 65 515264, +387 51 216526
E-mail: ponorac051@yahoo.com







Nenad Ponorac1, Amela Matavulj1, Nikola Grujić2, Zvezdana Rajkovača1 i Peđa Kovačević 1


Katedra za fiziolgiju Medicinskog fakulteta u Banjaluci 1
Zavod za fiziologiju Medicinskog fakulteta u Novom Sadu 2


Endemic nephropathy is a renal disease of unknown aetiology, which occurs endemically and affects individuals from risk families, with latent but progressive natural course and fatal outcome. In earlier territorial investigations, endemic areas were found along the Juzna Morava River: Brestovac, Kutles, Trupale, Gornja i Donja Toponica, Luzane, Nozrina, Moravac and other settlements. The last extensive studies of endemic nephropathy in these villages were conducted in 1981. These investigations showed that 2.7% of inhabitants along the right side of Juzna Morava River, in Donja Trnava village, suffered from endemic nephropathy. In the present study, a total of 291 persons (153 female and 138 male), aged 7 to 77, were investigated.  Diagnosis of endemic nephropathy was made according to the natural history, physical examination and urine analysis. Two persons or 0.68 % (one with chronic renal failure, and the other with an end-stage renal disease, on haemodialysis treatments) had endemic nephropathy. Eight persons (or 2.75%) suffered from other renal diseases. There were no urothelial tumors, which was confirmed in previous studies. Based on these investigations, a total of 39 persons from 29 risk families was selected for further examinations and following-up at the Institute of Nephrology and Haemodialysis in
Nis. Acta Medica Medianae 2005;44(4): 17 – 20.

Key words: endemic nephropathy, chronic renal failure