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Acta Medica Medianae
Vol. 46, No 4, December, 2005
UDK 61
YU ISSN 0365-4478

 

 

 


Contakt:

Voja Pavlovic
Institute of Phisiology, Faculty of Medicine .
81 Dr Zoran Djindjic Street
18000 Niš, Serbia and Montenegro
Phone: 018/334-221
E-mail: vojapav@yahoo.com

 

 

 

 

AScORBIc AcID MODULATES SPONTANEOUS THYMOcYTE APOPTOSIS

 

Voja Pavlović, Snežana Cekić, Vladmila Bojanić, Nenad Stojiljković i Goran Ranković

 

Institute of Physiology, Faculty of Medicine, Nis1
Institute of Pathophysiology, Faculty of Medicine, Nis2

 

 

The aim of the paper was to analyze the effect of various concentrations of ascorbic acid on spontaneous apoptosis of lymphocytes. About 58% of all thymocytes are subjected to a spontaneous apoptosis, after 24-hour cultivation in the complete medium. The number of apoptotic thymocytes was much lower in the culture with different concentrations of ascorbic acid. The most dramatic effect was detected in the culture with the highest concentration of ascorbic acid (10000 g/ml). In this culture, the number of apoptotic thymocytes was about 32%. These results, compared with the results of spontaneous apoptosis, show that the most significant inhibition of apoptosis was detected in the culture with 10000 g/ml of ascorbic acid. High concentration of ascorbic acid can inhibit spontaneous apoptosis of thymocytes.
Such inhibition of T cell apoptosis, as the effector cells in immune system, can represent one of the major factors by which ascorbic acid influence the immune system. Acta Medica Medianae 2005;44(4): 21 – 23.


Key words: ascorbic acid, thymus, apoptosis