Copyright 2006 by Faculty of Medicine, University of Nis
TUMORS OF THE KIDNEY AND URINARY TRACT IN ENDEMIC AREA OF VILLAGE BRESTOVAC
Twenty- five-year retrograde study
Radomir Raicevic*, Sladjana Miljkovic**, Sveto Susa***, Vojin Savic*, Rade Cukuranovic* and Branka Mitic*
During the twenty- five-year period the incidence of urothelial tumors was followed in the endemic village Brestovac. Thirty patients (3 of which with confirmed endemic nephropathy and 15 persons with suspected nephropathy) were investigated. Our retrograde study showed that there is a relationship between endemic nephropathy and urothelial cancer, and this association persisted with marked tendency to rise. Tumors were more common among males, aged from 50 to 70 years, with upper urinary tract urothelial cancer, papillary or trancellular forms, predominantly. Clinical feature showed classic triad of hematuria, flank pain and, rarely, flank mass, accompanied with non-specific symptomatology. Normal renal function was observed in 25 patients, but chronic renal failure was proven in five. Ten patients were treated by surgery, while 20 patients were treated by conservative therapy. There are no marked risk factors. Acta Medica Medianae 2006;45(2):17-20.
Key words: endemic nephropathy, renal tumor, urinary tract cancer