Copyright 2006 by Faculty of Medicine, University of Nis
THE INFLUENCE OF ARTERIAL HYPERTENSION ON THE LEFT VENTRICLAR DIASTOLIC FUNCTION
Suzana Milutinovic, Radovan Karadzic, Milan Pavlovic and Miloje Tomasevic
Polyclinic Varnava of Nis
The changes in the heart diastolic function are early functional disturbances in arterial hypertension and are present before the changes in the systolic function. The aim of this research was to study the influence of arterial hypertension on the left ventricular diastolic function. The research included a group of 126 subjects: 93 patients with arterial hypertension and 33 healthy subjects, who were the control group. The patients with arterial hypertension, compared to the control group, had a significantly higher: BMI (p < 0,001), left ventricular mass (p < 0,001), left ventricular mass index (p < 0,001) and the left atrium (p < 0,001). The parameters of the diastolic function in patients with arterial hypertension compared to the control group have shown statistically significant differences: IVRT (p < 0,001) and DT (p < 0,01) are significantly longer and the ratio E/A (p < 0,01) is significantly lower, which gives the image of delayed relaxation. The quotient of linear correlation of IVRT with the systolic and diastolic blood pressure has shown that IVRT statistically significantly correlates both with the systolic blood pressure (p < 0,005) and the diastolic blood pressure (p < 0,05). DT in correlations did not show the dependence on systolic and diastolic blood pressure. The quotient of the linear correlations of the E/A ratio with the systolic and diastolic blood pressure has shown that the E/A ratio, statistically significantly, negatively correlates with systolic blood pressure (p < 0,005) and diastolic blood pressure (p < 0,05). The changes in the left ventricular diastolic function in arterial hypertension are reversible and the condition for that is a good regulation of the blood pressure with hygienic and dietetic measures and medicaments. Acta Medica Medianae 2006;45(2):11-16.
Key words: arterial hypertension, diastolic function, systolic blood pressure, diastolic blood pressure, parameters of diastolic function