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Acta Medica Medianae
Vol. 45
No 4, October, 2006
UDK 61
YU ISSN 0365-4478
 

 

Contact:
Goran Damnjanovic
Zoran Djindjic nn
18000 Nis, Serbia
Phone: 018 508-834
E-mail: GORAN7328@bankerinter.net

 

 

Copyright 2006 by Faculty  of Medicine, University of Nis

SIGNIFICANCE OF ADHESIVE MOLECULES DETERMINATION IN ACUTE CORONARY SYNDROME

Goran Damnjanovic*, Ruzica Jankovic**, Zoran Damnjanovic***, Dragan Jovovic*, Biljana Jovovic#, Nevena Lecic#, Marija Jelic#, Boris Djinjdjic##, Dusan Sokolovic### and Dimitrios Koutsonanos&

Department of Internal Medicine, Military Hospital in Nis*
Clinic of Cardiovascular Diseases, Clinical Center inNis
**
Sanofi Aventis, Belgrade
***
Clinical-biochemical Laboratory, Military Hospital in Nis
#
Institute of Pathologic Physiology, School of Medicine in Nis
##
nstitute of Biochemistry, School of Medicine in Nis###
Hospital in Thessaloniki&

 Adhesive molecules play an important role in developing and progression of coronary atherosclerosis. The aim of the paper was to analyze a soluble form of vascular cell adhesive molecules 1 and intracellular cell adhesive molecules 1 in patients with acute coronary syndrome, which was compared with patients with stable angina pectoris and patients without coronary disease. Blood samples were taken from 15 patients with acute myocardial infarct (AMI), 15 patients with unstable angina pectoris (UAP), 15 with stable angina pectoris (SAP) and from 15 patients without coronary disease. The level of VCAM-1 is significantly higher in patients with AMI (799.826.3 ng/ml) compared with UAP (644.226.7 ng/ml), SAP (52632.5 ng/ml) and control group (27026.8 ng/ml). In the patients with UAP, VCAM-1 is significantly higher compared with SAP and control group. The level of VACM-1 is significantly higher in SAP group compared to control group. Serum concentration of ICAM-1 is similar in patients with AMI (424.115.2 ng/ml), UAP (40312.3 ng/ml) and SAP (381.216.2 ng/ml). Concentration of ICAM-1 is significantly higher in these groups compared with control group (244.311). Determination of VCAM-1 is useful for detection of coronary atherosclerotic plaque destabilization, while ICAM-1 is a useful indicator of atherosclerotic plaque presence in coronary vessels. Acta Medica Medianae 2006;45(4):28-31

Key words: adhesive molecules, acute coronary syndrome