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Acta Medica Medianae
Vol. 45
No 4, October, 2006
UDK 61
YU ISSN 0365-4478


Zorana Deljanin
Health Care Institute of Nis
50 dr Zoran Djindjic Street
18000 Nis, Serbia
Phone: 018/ 226 448, lokal 152



Copyright 2006 by Faculty  of Medicine, University of Nis


Zorana Deljanin, Natasa Rancic, Branislav Tiodorovc, Branislav Petrovic, Mirko Ilic, Zoran Velickovic and Roberta Markovic

Health Care Institute of Nis

Myocardial infarction (MI) is a complex disease that begins with a lifelong interaction between genetics and environmental factors. The aim of the study was to identify family history as a risk factor of myocardial infarction in examined population in the Municipality of Nis.
We used a case-control study with 100 patients with a first MI (in the period 1998-2000) and 100 controls, matched with respect to sex and age ( 2 years) from the Municipality of Nis.
Data was obtained from the epidemiological questionnaire. The Yates
c2 test, odds ratio-OR and their 99% interval of confident were used as statistical procedures.
The results showed that statistical significance for MI was present among all three degrees of relatives of subjects who have had an acute MI, and for hypertension, hypercholesterolemia and stroke among first and  second - degree relatives. The subjects with family history of hypercholesterolemia had 12.43 times higher risk of disease (p = 0,000) and in the case of family history of MI before the age of 55, the risk was almost 10 times (p = 0,000) higher. Almost 4 times higher risk of disease was registered in subjects with family history of hypertension (p < 0,00001) and stroke (before 65 years of age) - (p < 00005); a two-fold higher risk was registered in subjects with diagnoses of diabetes (p < 0,05) and other cardiovascular diseases (unless hypertension) (p < 0,01) in the nearest relatives before the age of 55.
We concluded that family history of diseases on the sample of the Municipality of Nis inhabitants was very important risk factor, mostly in the first-degree relatives. Genetic epidemiology is the future for all investigations between different population, and special attention should be paid to investigations and findings of different genes and loci which are very important for myocardial infarction occurrence, which would allow a new approach to preventive medicine. Acta Medica Medianae 2006;45(4):5-14. 

Key words: family history, risk factor, acute myocardial infarction