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Acta Medica Medianae
Vol. 46, No 1, January, 2007
UDK 61
YU ISSN 0365-4478

Correspondence to:
Dragan Lončar

Department of Obstetrics and Gynecology, Medical Center and Clinic

34000 Kragujevac, Serbia

Phone: 064/6168999,

E-mail: dloncar@ptt.yu








Copyright 2007 by Faculty  of Medicine, University of Nis


Dragan Loncar

Department of Obstetrics and Gynecology, Medical Center and Clinic in  Kragujevac


Micronucleus test is the method which is used in discovering the chromosome aberrations in the cells which are exposed to the effects of chemical mutagens. The cell which suffered the DNA damage cytologically fits to extranuclear bodies in cytoplasm, which represent the chromosomal fragments, the whole chromosomes or the groups of chromosomes. These cytoplasmic masses look like small cores, micronucleuses, and their size varies depending on the size of chromosome frag-ments or the number of chromosomes which are in the cytoplasm.

The aim of the paper was to examine the influence of monophased, combined, low-dosed contraceptive pills which contain ethinyl- estradiol and gestoden on the micronucleus frequency in human lymphocytes of peripheral blood and their influence on the lipid status of the users.

We examined 30 patients older than 18 years. All the patients took part in the research in order to prevent unwanted pregnancy.The existence of cardiovascular, endocrinological, neurological and malignant diseases was excluded by using clinical examinations, biochemical, hematological and additional researches.

After the therapy of 20 g of ethynil- estradiol and 75 g of gestoden in the period of six consequtive menstrual cycles in order to prevent unwanted pregnancy, there was not statistically significant change of micronucleus frequency in lympho-cytes of peripheral blood in the cases of patients which took part in the research; (p> 0,05).

The therapy significantly increases the value of cholesterol, low- density lipo-proteins (LDL) and triglycerides in the blood of the patients (p< 0,05).

The therapy can be applied along with the regular control of the gynecologist in order to prevent unwanted pregnancy. Acta Medica Medianae 2007;46(1):11-16.


Key words: gestodene, ethinyl estradiol, micronuclei, genotoxicity, lipoproteins


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