Acta Medica Medianae
18000 Niš, Srbija
Copyright 2007 by Faculty of Medicine, University of Nis
PATHOGENETIC ASPECTS OF ATHEROSCLEROSIS
Atherosclerosis is a chronic progressive disease, which develops from the moment of birth. Lipid deposit in blood vessel intima leads to gradual stenosis and impeding blood flow through tissues and eventually results in broad spectrum of clinical manifestations. Clinical manifestations are the consequence of plaque rupture which induce trombogenesis and formation of thrombus and embolus. In this way, the process of thrombogenesis is followed by obstruction of blood vessels. Elimination of risk factors such as obesity, hyperlipidemia and hypertension, improves endothelial function and reduces progression of atherosclerosis. Acta Medica Medianae 2007;46(1):25-29.
Key words: atherosclerosis, risk factors, plaque evolution