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Acta Medica Medianae
Vol. 46, No 2, April, 2007
UDK 61
YU ISSN 0365-4478




Correspondence to:
Mirjana Bakić

18000 Niš, Srbija

Tel. : 018/253666


Copyright 2007 by Faculty  of Medicine, University of Nis



Mirjana Bakic



Endothelium plays an important role in maintaining normal vascular tonus and blood fluidity reducing thrombocyte activity and adhesion of leukocytes as well as limiting response of vascular inflammation. However, in certain pathological conditions such as hypercholesterolemia, hypertension, and diabetes, endothelium improves vasoconstriction, inflammation and thrombocytic events.

Non-pharmacological concept is based on recognition of genetic factors, environmental factors, or combination of risk factors for the occurrence of endothelial dysfunction, general and individual education of the significance of adequate nutrition, physical activity and regulation of body weight, regular check-ups and the application of antioxidants which can regulate and protect several aspects of endothelial functions. Acta Medica Medianae 2007;46(2):63-67.


Key words: endothelium, endothelial dysfunction, non-pharmacological concept

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