Acta Medica Medianae
Copyright 2008 by Faculty of Medicine, University of Nis
GENDER-RELATED DIFFERENCES IN INFLAMMATORY AND LIPID PARAMETERS IN PATIENTS WITH DIABETES MELLITUS TYPE 2
Dejan Ilic, Milica Pesic, Todorka Savic, Natasa Stankovic and Boris Djindjic
Diabetes mellitus type 2 (DM type 2) is one of the most common health problems worldwide. Diabetics have increased risk for development of wide spectrum of atherosclerotic complications, at the basis of which are inflammation and diabetic dyslipidemia. Increasing of relative risk for coronary artery disease development is higher in females with DM type 2.
The aim of this study was determination of characteristic inflammatory and lipid disorders in type 2 diabetics and their association with patient gender.
The study involved 35 patients with DM type 2 and stabile angina pectoris. Besides anamnesis, all patiens underwent clinical examinations (measure of blood pressure, body height and weight and calculation of body mass index). Inflammatory markers (sedimentation in I and II hour-SE I and SE II, C reactive protein-CRP, fibrinogen concentration and leukocyte count) as well as lipid parameters (total cholesterol, LDL and HDL cholesterol concentration and triglycerides) were determined in all the patients.
Total cholesterol and triglycerides concentrations were higher in females with DM type 2 compared to males (p<0,05). There were not significant gender differences in HDL and LDL cholesterol concentration. All inflammatory markers (SE I and SE II, CRP, fibrinogen concentration and leukocyte count) were higher in females with DM type 2 and CAD compared to men (p<0,05). In males, there was a strong postive correlation between SE I and SE II with total LDL (p<0,05) and HDL cholesterol concentrations (p<0,01). Concentration of CRP was only significantly connected with triglycerides concentration (p<0,05). There was a strong association between leukocyte count and increased triglycerides (p<0,05) and low HDL cholesterol concentration (p<0,01). In females, there was only a strong positive correlation between SE II (p<0,01) and CRP concentration (p<0,05) and triglycerides.
Women with DM type 2 and clinically manifest CAD (stable angina pectoris) are at higher risk for development the cardiovascular complications as they have more prominent lipid and inflammatory disorders than men. Acta medica Medianae 2008;47(3): 39-43.
Key words: diabetes mellitus, inflammation, lipid disorders, dyslipidemia