Acta Medica Medianae
Differences in the levels of lipid status IN patients with ischaemic heart disease and malignant disease
Beretka Atila, Branislava Brkic, Miodrag Djordjevic and Dragan Zecevic
Medicinski fakultet US Medical School Beograd1
Specijalna bolnica za srce i krvne sudove "Ostrog" Beograd2
Arteriosclerosis is the basis of all cardiovascular diseases. Numerous risk factors lead to the rise of malignant and cardiovascular diseases. Those are: elevated artery blood pressure, raised plasma cholesterol and triglycerides, low level of HDL-cholesterol, smoking, diabetes mellitus, diet, lack of physical exercises, heredity, stress, gender.
The aim of the study was to compare the lipid status of patients with cardiovascular disease or malignancy.
The database of the biochemical laboratory and oncology counselling unit of the "Ostrog Clinic" was used. The method of random sample was used and patients (n=29) of both genders were selected, aged 40 to 47 years, with cardiovascular diseases, and had significant occlusive coronary disease, which required operation or surgical revascularization procedure. The patients were classified in two groups: G1 (n=14) with statin therapy and G2 (n=15) without statin therapy. Both groups were statistically compared with a group of female patients (n=30) with breast cancer, who were between 37 and 69 years of age. Control group comprised 25 healthy subjects. Standard statistical methods were used for processing the lipid status parameters: the arithmetic mean, standard deviation SDn and SDn-1, correlation coefficient, post hock test and a single factor analysis of variance.
The results obtained pointed to the existence of a marked hyperlipoproteinemia type 4 in the group of cardiovascular patients who did not use statin (G2). In G2, higher levels of cholesterol, LDL-cholesterol and plasma triglycerides in comparison with the control and G1, while the value of HDL-cholesterol was within the range of referent values. The obvious suppressing effect of statin on cholesterol and LDL-cholesterol was observed in G1. Group G3 had, in comparison with the control and cardiovascular patients, significantly lower levels of cholesterol and triglycerides in plasma, as well as lower index of atherosclerosis and lower risk factors for the development of atherosclerosis.
Elevated levels of cholesterol, LDL-C and LDL/HDL-C are the important risk factors for atherosclerosis development. These lipids’ risk factors could be modified, especially in the primary prevention of cardiovascular diseases. Lower values of lipid parameters in patients with malignancy compared to patients with cardiovascular diseases indicated possibble lower risk for malignancy in these patients. Acta Medica Medianae 2008;47(4):20-23.
Key words: lipid status, cardiovascular disease, risk factors, malignant disease