|Editorial  board | About the Journal   | Instructions for Authors | Peer Review Policy | Clinical and Experimental Work Code |   Contact  |

Acta Medica Medianae
Vol. 48, No1 , Januar, 2009
UDK 61
YU ISSN 0365-4478


Correspondence to:
Sanja Perić

Centar estetske medicine, Dom zdravlja

Vojvode Tankosića 15

18000 Niš, Srbija

Tel.: +38118210999,

E-mail: sanjasasa@bankerinter.net









Original article




Sanja Perić¹, Maja Bubanj², Saša Bubanj³, Ratko Stanković³


Centar estetske medicine-Dom zdravlja u Nišu¹,

Apotekarska ustanova u Nišu²,

Fakultet sporta i fizičkog vaspitanja u Nišu³


The introduction of retinoids for the treatment of acne vulgaris in the 1970′s was  revolutionary in dermatology. For the first time, dermatologists had effective comedolytic medication that could attenuate multiple aspects of acne pathogenesis, resulting in superior clinical and cosmetic outcomes. The quest for more stable molecules able to produce therapeutic effects similar to tretinoin lead to the evolution of adapalen, which has completely new chemical composition attained as a derivate of naphtoic-acid. Nowadays, the accepted opinion is that acne is accounted by multifactor processes, i.e. that there are many elements which determine the course of disease in pilosebaceous folicle. Ideal topical treatment of acne vulgaris could acheive therapeutic effects at four key components of this pathogen process: abnormal keratinization, proliferation and differentiation, augmented creation of sebum, settlement of pilosebaceous unit from Propionbacterium acnes (P. acnes) and inflammatory reaction on antigenes and mediators which  originate from P. acnes. The aims of this research were to establish the efficiency of treatments with adapalen, to establish eventual undesirable effects of this therapy, quality of life during the therapy and  importance of home attendance.The research included 35 subjects. The selection of subjects was based on clinical analysis and anamnestic data. The research was conducted in the Centre of Esthetic Medicine in the Primary Health Care Centre in Nis. The subjects of experimental subsample (20 of them) applied adapalen (Airol cream), Pantenol gel cream and Plantoderm unquent (Actavis co) for night use. Subjects of control subsample applied only Pantenol gel cream and Plantoderm unquent (Actavis co) for nightly usage. The research lasted 12 weeks. All subjects underwent complete treatment. The subjects of experimental subsample treated with adapalen showed visible amelioration after second therapy, and results were clear after four weeks of treatment. Undesirable effects mostly appeared during the second and third week and were present untill the end of the therapy, but they did not significantly affect the positive results. Acta Medica Medianae 2009;48(1): 24-30.


Key words: adapalen, topical retinoid, acne vulgaris