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Acta Medica Medianae
Vol. 48, No4, December, 2009
UDK 61
YU ISSN 0365-4478


Correspondence to:

Rade Stefanović

Fakultet sporta i fizičke kulture, Univerzitet u Prištini-Leposavić

E-mail: becks_beli@hotmail.com




Original article
UDK: 612.017:796.42.015.1






Rade Stefanović1, Ljubiša Lilić1, Vladimir Mutavdžić2, Tatjana Popović-Ilić1, Jadranka Kocić1, Nataša Đinđić, Ana Pražić3 i Lela Milošević4


Faculty of Physical Education and Sport In Pristina - Leposavic1

Faculty of Sports and Physical Education, University of Niš, Serbia2

Neurology Clinic, Clinical Center Niš3

Health Care Center Nišu4



       Regular physical activity and good physical fitness are widely accepted as factors that reduce all-cause mortality and improve a number of health outcomes. The aim of this study was to investigate the effects of intensive aerobic exercise training program on systemic inflammatory markers in young healthy athletes.

       The investigation involved fifteen healthy athletes with the aim to investigate the effect of intensive physical training program on inflammatory response, and systemic inflammatory markers. Mean age of athletes was 16–20 years. The training period lasted minimum six months. All athletes trained 3 times/week. Blood samples were taken from the antecubital vein, in the morning, immediately before training; post-exercise blood samples were taken 5–10 min immediately after the exercise session. Cardiovascular parameters, inflammatory markers and physical exercise-related symptoms were determined.

       Ten male and five female athletes with mean age 18.031.4 years were included in the investigation. There was not a significant difference in systolic blood pressure, but significant reduction of diastolic blood pressure and increasing of heart rate (p<0.05) were registered after completion of exercise. Significant increase in SE I and lukocyte count as well as neutrophile predomination were found after the exercise. The lymphocyte stake was significantly decreased after intensive training. The training-related symptoms were more frequent at the beginning of the training program. Breathlessness was experienced more frequently (36%) than wheezing (12%), cough (16%), weakness (16%) or chest tightness (12%) at the beginning of the program.

      Regular physical activity reduces the risk of cardiovascular and atherosclerotic diseases. The concentration of CRP during exercise training program is a useful marker for determination of athletes’ physical condition and their response to the training program intensity. Only well-balanced exercise training programs result in favorable effects on the immune system, which is manifested through reduction of inflammation, increased immune response and reduction of physical exercise-related symptoms. Acta Medica Medianae 2009;48(4):50-54.


Key words: inflammation, inflammatory markers, athletes, physical training