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Acta Medica Medianae
Vol. 49, No1, March, 2010
UDK 61
YU ISSN 0365-4478


Correspondence to:

Dhastagir Sheriff

Department of Biochemistry

Al Arab Medical Unviersity Benghazi, Libya

E-mail: dhastagir@yahoo.ca






Review article
UDC: 616.697: 577.1





Elshaari F. A., Fatum A. E.and Sheriff D. S.


                        Department of Biochemistry, Al Arab Medical Unviersity, Benghazi, Libya




Infertility has become a common occurrence in males. Oxidant stress has become one of the most common causes of infertility. X-irradiation, or exposure to environmental toxicants and the physical conditions of varicocele and cryptorchidism have been demonstrated to increase testicular oxidative stress. The resultant oxidant stress may lead to an increase in germ cell apoptosis and subsequent hypospermatogenesis. This may result in changes in the dynamics of testicular microvascular blood flow, endocrine signaling, and germ cell apoptosis. Oxidative stress, therefore, becomes a major and the most probable finding associated with male infertility. This raises a possibility of application of antioxidant therapy that could help alleviate the reduced spermatogenesis. Acta Medica Medianae 2010;49(1):48-53.


Key Words: oxidative stress, testis, male infertility, apoptosis