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Clinic of Gynecology and Obstetrics
Clinical Center Niš
Bul. dr Zorana Đinđića 48, 18000 Niš
FREQUENCY OF CERVICAL INTRAEPITHELIAL NEOPLASIA AND CARCINOMAS IN WOMEN WITH AND WITHOUT BACTERIAL VAGINOSIS
Zoran Janjić1, Zoran Pop Trajković1, Miroslav Folić2, Jasmina Popović1, Aleksandra Petrić1 and Predrag Vukomanović1
Clinic of Gynecology and Obstetrics, Clinical Center Niš, Serbia1
Faculty of Medicine, University of Kragujevac, Serbia2
Bacterial vaginosis is one of the most frequent disorders of vaginal ecosystem in women during their reproductive life. The first concept in the pathogenesis of bacterial vaginosis points out that the unfamiliar initial influence on vaginal ecosystem decreases lactobacillus concentration, which results in the increase of vaginal secretion pH and multiplication of Gardnerela vaginalis and other anaerobes.
The aim of this study was to compare the frequency of cervical neoplasia in women with and without bacterial vaginosis.
The research included 158 patients, between 18 and 51 years of age, at the Clinic of Gynecology and Obstetrics in Niš. Clinical processing of patients consisted of cytological, colposcopic and pathohistological examinations. Bacterial vaginosis was, beside clue cell detection with native preparation, diagnosed by the application of other Amsel’s criteria: presence of characteristic vaginal secretion, positive amino test, values of vaginal secretion pH over 4.5.
The results showed that 23.42% of the patients had bacterial vaginosis. The greatest percent of the patients with bacterial vaginosis (24.32%) was between 20 and 34 years of age. In the examined population, 7.59% of the patients had positive pathohistological finding. The number of normal pathohistological findings was statistically significantly lower in the patients with bacterial vaginosis (75.68%) than in those without bacterial vaginosis (97.52%), (c2=16.28, p<0.001). Acta Medica Medianae 2011;50(1):5-10.
Key words: bacterial vaginosis, cervical neoplasia, sexually transmitted diseases, frequency