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Acta Medica Medianae
Vol. 50, No 2, June, 2011

UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)

 

Correspondence to:

Vitošević Biljana

Dositeja Obradovića bb

38218 Leposavić, Srbija

E-mail: biljana.vitosevic@pr.ac.rs

Review article                                                                                          

UDC: 612.74                                    

doi:10.5633/amm.2011.0211

 

 

ROLE OF PPAR-* IN DETERMINATION OF MUSCLE FIBER TYPE IN RESPONSE TO EXERCISE

 Biljana Vitošević, Goran Ranković and Tatjana Popović-Ilić1

 

Department for Medical Subjects, Faculty for Sport and Physical Education, Leposavić, University of Priština, Serbia1

Institute of Physiology, Faculty of Medicine in Niš, University of Niš, Serbia2

 

Endurance exercise can induce muscle fiber type change from type II glycolytic to oxidative type I muscle fibers. The exact molecular mechanism is still not clear, but the nuclear receptor PPAR-* (peroxisome proliferator-activated receptor delta) and co-activator, perxisome-proliferator-activated receptor-gama co-activator-1" (PGC-1") are the key factors responsible for increased mitochondrial biogenesis and increased oxidative capacity of muscle fibers, determining in this way the muscle phenotype. The paper explores the possible mechanisms of regulation and the role of PPAR-* in the skeletal muscle and muscle fiber type determination in order to find solutions for complex physiological properties, such as fatigue and endurance. Acta Medica Medianae 2011;50(2):57-62.

 

Key words: nuclear receptor, muscle fiber type, exercise