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Acta Medica Medianae
Vol. 50, No 2, Jun, 2011

UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Aleksandar Janković

Klinika za kožne i polne bolesti

Klinički centar Niš

Bulevar dr Zorana Đinđića 48

18000 Niš, Serbia

E-mail: jakesnage@yahoo.com

Short Communication


doi: 10.5633/amm.2011.0207      


Evaluation of healing effects of new herbal formulation on venous leg ulcer: pilot study

Ivana Binić1, Aleksandar Janković1, Milan Miladinović2, Đorđe Gocev3,

Dimitrije Janković4 and Zoran Vrućinić5


Clinic of Dermatovenerology, Clinical Center Niš, Serbia1

Faculty of Medicine, University in Priština, Serbia2

Clinic of Dermatovenerology, Clinical Center Skopje, Republic Of Macedonia3

Faculty of Medicine , University of Belgrade, Serbia4

Clinical Center Banja Luka, Bosnia and Herzegovina5   



Venous leg ulcers represent a significant public health problem that will increase as the population ages. A wide variety of agents are available for the treatment of venous leg ulcers, including ointments and dressings. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent and etc.

The aim of the study was to establish the healing effects of herbal therapy on non-infected venous leg ulcers. The major components of the DermaplantG were extract of Allii bulbus, Hyperici herba and extract of Calendulae flos. In the study were included 18 patients with venous leg ulcers treated by DermaplantG herbal therapy. Our investigation focused on the five controls (baseline, 1st , 3rd, 5th 7th weeks) of the parameters changes important for ulcer healing: wound surface area and reduction of venous leg ulcer score (fibrin deposits, exudation and eczema). Within-treatment analysis showed that, following DermaplantG herbal treatment, there was a significant decrease in surface leg ulcer and venous leg ulcer score after 7th treatment week (P < 0.05). The results of this pilot study demonstrate healing and antimicrobiologic efects of herbal therapy on non-infected venous leg ulcer. Acta Medica Medianae 2011;50(2): 39-42.


Key words: DermaplantG herbal therapy, healing, venous leg ulcer