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Clinic of Dermatology and Venerology
Clinical Center Niš
Bulevar dr Zorana Đinđića 48
18000 Niš, Serbia
Antimicrobiological effects of new natural antiseptic formulation on non-infected venous leg ulcer: pilot study
Ivana Binić1, Aleksandar Janković1, Milan Miladinović2, Đorđe Gocev3, Dimitrije Janković4
and Zoran Vrućinić5
Clinic of Dermatology and Venerology, Clinical Center Niš, Serbia1
University of Priština, Faculty of Medicine in Priština, Serbia2
Clinic of Dermatovenerology, Clinical Center Skopje, Republic Of Macedonia3
University of Belgrade, Faculty of Medicine, Belgrade, Serbia4
Clinical Center Banja Luka, Bosnia and Herzegovina5
Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as antimicrobial, antifungal, astringent etc. The aim of the study was to establish the in-vivo antimicrobial effects of herbal hydrogel formulation DermaplantG. The major components of the DermaplantG were the extracts of Allii bulbus, Hyperici herba and extract of Calendulae flos. A total of 12 patients with non-infected venous leg ulcers were treated twice daily, for 5 weeks, with new hydrogel formulation. All ulcers showed clinical signs of contamination or colonization without signs of systemic infection. Premoistening the swab with sterile saline was considered when the surface of the wound was dry. The tip of the swab was rolled on its side in a zigzag pattern for at least one full rotation. Standard methods for isolation and identification of aerobic and anaerobic bacteria were used.
On baseline assessment, a large number of different types of bacteria were detected in all venous leg ulcers. S. aureus and P. aeruginosa were isolated from almost all controls.
On baseline, mixed bacterial flora (50%) was isolated in six venous leg ulcers (five ulcers with S. aureus-P. aeruginosa and one ulcer with E.coli-Enterobacter spp-P.aeruginosa). At the end of the treatment in DermaplantG group in 8 venous ulcers were detected S. aureus (66.66%) and P. aeruginosa (16.66%), and one venous leg ulcers was detected as sterile (8.33%). The number of different types of isolated bacterial species decreased significantly (P<0.05) after the use of DermaplantG herbal preparations. Therapy in DermaplantG group was administered without any side effects.
The preliminary results of this pilot study demonstrate potential antimicrobial effects of herbal therapy on non-infected venous leg ulcers. Acta Medica Medianae 2011; 50(3):40-44.
Key words: venous leg ulcer, microbiological flora, DermaplantG hydrogel