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Acta Medica Medianae
Vol. 50, No 4, December, 2011

UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Marija Vukelić

University of Niš

Faculty of Medicine

Bul dr Zoran Đinđić 81

18000 Niš, Serbia


Original article    


UDC: 616.314-089.8:615.46






Marija Vukelić1, Žarko Mitić2, Miroslav Miljković3, Jelena Živković1, Nenad Ignjatović4, Dragan  Uskoković4, Perica Vasiljević5, Marija Petković1, Jelena Živanov-Čurlis1 and Stevo Najman1


University of Niš, Faculty of Medicine, Institite of Biology and Human genetics, Niš, Serbia1

University of Niš, Faculty of Medicine, Department of Pharmacy, Niš, Serbia2

University of Niš, Faculty of Medicine, Laboratory for Electron Microscopy, Niš, Serbia3

Institute for Technical Sciences SANU, Belgrade, Serbia4

University of Niš, Faculty of Nature and Sciences, Biology and Ecology Department, Niš, Serbia5




The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery. Acta Medica Medianae 2011;50(4):35-39.


      Key words: biomaterials, HAp/PLLA, SBF, SEM, EDS