| Početna strana | Uredništvo | Časopis  | Uputstvo autorima  | Kodeks u  kliničkom i eksperimentalnom radu | Kontakt  |  
| Home page | Editorial  board | About the Journal | Instructions for Authors | Peer Review Policy | Clinical and Experimental Work Code | Contact  |


Acta Medica Medianae
Vol. 51, No 3, September, 2012

UDK 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Olivera Krstić

Municipality of Niš, Serbia

E-mail: dkrle@jotel.co.rs 

Review article                                                         

UDC: 616.1-08:613.72:616-008.9






Olivera Krstić1, Igor Ilić2, Jasmina Ranković3, Gorana Nedin Ranković4, Nataša Đinđić4, Todorka Savić4, Slađan Karalejić2, Branimir Mekić2, Vesko Milenković2 and Dragan Toskić2

Municipality of Niš, Serbia1

University of Priština, Faculty of Sport and Physical Education, Leposavic, Serbia2

Primary Health Care Center Niš, Serbia3

University of Niš, Faculty of Medicine, Niš, Serbia4


Insufficient physical activity in the world annually is the cause of death of 1.9 million people. According to the data from the World Health Report, physical inactivity is about to become the global problem. Regular physical activity and good physical shape raise the functional capacity and the quality of patient’s life. With physical activity it is possible to improve metabolic, endothelial, lateral-muscular, pulmonary and cardiovascular functions of an organism, but also the function of the autonomous nervous system. The endothelium has the important role in maintaining the normal cardiovascular tonus and blood fluidity by reducing the platelet activity and the adhesion of leukocytes, and also by restricting the reaction of vascular inflammation. The aim of this paper was to present the recent data about effects of cardiovascular rehabilitation and physical training on lipoproteins’ status and markers of endothelial function.

The impact of physical activity on the lipid status is accomplished by affecting the enzymes of lipoprotein metabolism, including the lipoprotein and the liver lipase and the movable protein of cholesterol ester (11). The studies point out that aerobic physical activity result in increasing of HDL concentration  and the decrease of the triglycerides value, total and LDL cholesterol. The connection, which is dose-dependant, exists between physical activity and the lipid level, as the arguments which suggest that the duration of physical activity is the key parameter in modification of the lipid metabolism.

Physical activity leads to the beneficial changes in the cardiovascular and lipid indicators and improves the endothelial function in the secondary prevention of coronary disease. Reduction of the lipid parameters by introducing physical rehabilitation and dietetic regime lie in the basis of secondary prevention of coronary disease. Furthermore, there is a constant improvement in NO biodisposability and therewith the improvement in endothelial function. Acta Medica Medianae 2012;51(3):52-56.


      Key words: carcinoid, gastrointestinal tract, neuroendocrine tumours, serotonin, carcinoid syndrome