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Acta Medica Medianae
Vol. 53, No 1, March, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Dragana Veličković,

Institute of Physiology

 Faculty of Medicine

Bul.dr. Zorana Đinđića 81, 18000 Niš

E-mail: velickovicdr@gmail.com

Original article                                                                            UDC: 547.72:616.127






Dragana Veličković1, Branislava Miličić2, Tanja Mladenović3


University of Niš, Institute of Physiology, Faculty of Medicine, Niš, Serbia1

University of Ljubljana, Institute for Pathology, Faculty of Medicine, Ljubljana, Slovenia2

University of Niš, Institute of Pathophysiology, Faculty of Medicine, Niš, Serbia3


Furfural is produced by dehydration process when strong acids react with pentoses and formation of furfural occurs. It is used as a solvent for extracting mineral oils in many industrial branches and can also be found in orange juice or in brandy. Furfural is not toxic, but its oxidative by-product, pyromucic acid that is conjugated to glycine in the liver and excreted mostly in urine, has harmful effects.

The experiments were performed on 9-week old Wistar rats with body weight of about 259 gr. The animals were treated with furfuraldehyde C4C3OCHO, “Sigma chemical Co”, as 1% solution in drinking water, first at a dose of 20mg/kg body weight for seven days, then the dosage was gradually increased  for 45 days when the animals were sacrificed.

The analysis was performed on the myocardium of experimental animals. The methods of Hematoksilin-oesin staining (HE) and PAS (periodic acid Shiff) staining were used. Toxic changes were detected in myocardiocytes, showing partial loss of striation, sporadic discoloration of the nucleus and cytoplasm coagulation associated with the presence of expressed hyperemia and the massive loss of glycogen in cardiomyocytes as well. Acta Medica Medianae 2014;53(1):5-9.


            Key words: furfural, glycogen in cardiomyocytes