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Acta Medica Medianae
Vol. 53, No 1, March, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Milica Petrović

Vizantijski bul. 32/9, 18000 Niš, Serbia

E-mail: petrovicmilica21@gmail.com

Review article        


UDC: 547.913:616.31-002.828




 Milica Petrović1, Milica Kostić2, Milena Kostić1 3, Nebojša Krunić1,3, Marko Igić1, Zoran Pešić3,4, Suzana Otašević5,6


Department of Prosthodontics, Faculty of Medicine, University of Niš, Niš, Serbia1

Department of Pharmacy, Faculty of Medicine, University of Niš, Niš, Serbia2

Clinic of Dentistry Niš, Niš, Serbia3

Department of Maxillofacial Surgery, Faculty of Medicine, University of Niš, Niš, Serbia4

Department of Microbiology and Immunology, Faculty of Medicine, University of Niš, Niš, Serbia5

Public Health Institute Niš,Serbia6


Denture stomatitis is a common inflammatory reaction affecting denture wearers, multifactorial etiology, which is usually associated with Candida species, particularly Candida albicans. The treatment of Candida-associated denture stomatitis (CADS) is difficult and complex due to its multifactorial etiology, common recurrences, as well as the lack of antifungal drug efficacy. This review aims to critically discuss several key factors affecting adhesion and biofilm formation of Candida species on acrylic surface, as well as the use of herbs, proposed as an alternative in the treatment of CADS. Many factors affect adhesion and biofilm formation of Candida spp.  on acrylic surfaces, such as surface roughness of the inner surface of the prosthesis, salivary pellicle, hydrophobic and electrostatic interactions. Having in mind that denture stomatitis is a common disease in total denture wearer, that it is most common in fungal etiology and that biofilm development increases yeast resistance, application of non-synthetic, completely natural substances, such as essential oils and extracts, may be suggested as a promising alternative for treatment of CADS. Acta Medica Medianae 2014; 53(1):73-79.


Key words: Candida-associated denture stomatitis, Candida albicans, essential oils, plant extracts