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Acta Medica Medianae
Vol. 53, No 1, March, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Zoran Damnjanović

Vascular Surgery Clinic

Clinical Center of Niš

Bulevar Zorana Đinđića 48

18000 Niš, Serbia

E-mail: damnjanovicz@yahoo.com

Original article                                          UDC: 577.1:616.36-008.6]:616.366-003.7




Connection between markers of cholestasis and intensity of oxidative modification of proteins in patients with choledocholithiasis


Zoran Damnjanović1, Milan Jovanović1,2, Aleksandar Nagorni2,3, Dušan Sokolović2, Milan Radojković2,4, Goran Damnjanović5, Boris Đinđić2, Dragutin Grozdanović1, Mlađan Golubović1



Vascular Surgery Clinic, Clinical Center Niš, Serbia1

Faculty of Medicine, University of Niš, Serbia2

Clinic of Gastroenterology and Hepatology, Clinical Center Niš, Serbia3

General Surgery Clinic, Clinical Center Niš, Serbia4

Department of Internal Medicine, Military Hospital Niš, Serbia5


The aim of this study was to examine the connection between cholestatic markers and the oxidative protein modification intensity in patients with choledocholithiasis. All the participants were subjected to clinical, laboratory and ultrasonic check-up at the Internal Department of the Military Hospital in Niš, Serbia. The parameters of oxidative stress: carbonyl groups, a measure of oxidative protein modification, and biochemical markers of cholestasis were determined by standard biochemical methods. The concentration of total (r=0.41, p<0.05), direct (r=0.49, p<+0.01) and indirect (r=0.41, p<0.05) bilirubin was in statistically significant positive linear correlation with the intensity of oxidative modification of proteins, while the other biochemical markers of cholestasis did not show such correlation. Total, direct and indirect bilirubins showed a significant positive correlation with oxidative protein modification, assessed through the levels of carbonyl groups in patients with choledocholithiasis. Acta Medica Medianae 2014;53(1):10-14.


Key words: cholestasis, intensity of oxidative modification of proteins, choledocholithiasis