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Acta Medica Medianae
Vol. 53, No 4, December, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Miljan Zindović

Surgery Clinic, Clinical Center of Montenegro

Ljubljanska bb, Podgorica, Montenegro

E-mail: mzindo@yahoo.com

Case report                                                                             UDC: 616.33/.34-006-076.5-089 doi:10.5633/amm.2014.0407








Miljan Zindović1, Velimir Milošević2, Janko Žujović1, Ljiljana Vučković3, Aleksandar Kujović1, Ranko Lazović1



Center for Abdominal Surgery, Surgery Clinic, Clinical Center of Montenegro, Podgorica, Montenegro1

Clinic of Internal Medicine – Gastroenterology, Clinical Center of Montenegro, Podgorica, Montenegro2

Institute of Pathology, Clinical Center of Montenegro, Podgorica, Montenegro 3


Gastrointestinal stromal tumors (GIST-s) are the most common mesenchimal tumors. They occur usually in older age, through the whole digestive tube, but predomi-nantly in the stomach (60%), and most rarely in oesopagus (<1%). Symptoms and signs of GISTs depend on the size and localization of the tumor. Diagnosis is based on pathohistological analyses that include immuno-histochemical staining. Prognosis of these tumors depend of mitotic index, size of tumor, localization, presence of necrosis, bleeding in tumor, infiltration of mucosa and serosa, presence of lymphogenic and liver metastasis. Regarding these parameters, GISTs are classified as high, intermediate, low or very low risk tumors. Standard therapy for GISTs is surgical treatment, and adjuvant treatment with inhibitors of tyrosine kinase depends on risk stratification. In this paper, the case of 37-year old male with giant GIST of extraintestinal localization is described. Tumors of this localization are extremely rare, and data about this issue in literature are scarce. Acta Medica Medianae 2014;53(4):37-41.


Key words: giant GIST, CD117, CD34, surgical treatment, Imatinib