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Acta Medica Medianae
Vol. 53, No 4, December, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:

Vladimir Živković

Faculty of Medicine

Bul. Zorana Đinđića 81, Niš, Serbia

E-mail: vladimirzix@gmail.com

Original article                                                                    

 UDC:616.22-006.04-036                                                                                                    doi:10.5633/amm.2014.0402



Epidemiological characteristics of larYngeal cancer

in the population of the Nišava District


Vladimir Živković1, Nataša Rančić1,2, Jelena Ignjatović1, Bojan Stošić3, Ivana Stanković4


University of Niš, Faculty of Medicine, Serbia1

Public Health Institute Niš, Center for Disease Control and Prevention, Niš Serbia2

Military Medical Academy, Clinic for Oncology, Beograd, Serbia3

University f Kragujevac Faculty of Medicine, Serbia4



The objective of the paper was to evaluate the epidemiological characteristics of laryngeal cancer in the Nišava District in the last 10 years.

Published data from the Population Cancer Registry (Serbia) for the period 1999 to 2008 was used. Age-standardized incidence and mortality rates were calculated, ac-cording to the standard world population. The rates were calculated per 100.000 inhabi-tants. Population data were obtained from the National Census 2002. Linear trend was cal-culated, too.

During the period 1999-2008, a total number of 440 cases of laringeal cancer was registered – there were 401 (91.1%) males and 39 (8.2%) females. The average age of patients was similar (male: 61.710.97 vs female: 61.812.3). In the observed period, the average annual standardized incidence rate was 75.39 (145.77 in males and 11.16 in females). Value of linear incidence trend in males was Y=0.5565x+9.422, R2=0.4554 compared tothe linear incidence trend of laringeal cancer in females Y=0.1426x+0.3807, R2=0.3347. During the entire observation period, a total number of 189 deaths of la-ringeal cancer was registered, 176 (93.1%) in males and 13 (6.9%) in females. The ave-rage annual-standardized mortality rate was 15.14 (29.67 in males and 0.17 in females). Value of mortality trend in males was Y=0.5238x+1.3333, R2= 0.4394 compared to the value of mortality trend in females Y=0.0143x+0.3663, R2= 0,0558. In 204 (80.3%) pa-tients, the histological type of cancer was squamous cell carcinoma. According to loca-lization, approximately two thirds had a glottic cancer while one-third of the cancers were supra- or subglottic cancers.

The research period showed that men suffered more and died from laryngeal cancer, i.e. a slight increase in disease incidence and mortality was observed in men, whereas in females only increase in disease incidence was observed. Acta Medica Medianae 2014; 53(4):10-14.


Key words: incidence, laryngeal cancer, mortality