| Početna strana | Uredništvo | Časopis  | Uputstvo autorima  | Kodeks u  kliničkom i eksperimentalnom radu | Kontakt  |  
| Home page | Editorial  board | About the Journal | Instructions for Authors | Peer Review Policy | Clinical and Experimental Work Code | Contact  |


Acta Medica Medianae
Vol. 53, No 4, December, 2014

UDC 61
ISSN 0365-4478(Printed version)
ISSN 1821-2794(Online)


Correspondence to:


Žarko Mitić

Faculty of Medicine, Niš, Serbia

Bul.dr Zorana Đinđića 81, 18000 Niš, Serbia

E-mail: zak_chem2001@yahoo.com

Review article                                                                                           UDC: 577.114.7:616-085








Žarko Mitić1, Milorad Cakić2


University of Niš, Faculty of Medicine, Niš, Serbia1

University of Niš, Faculty of Technology, Leskovac, Serbia2



In the field of medicinal chemistry, a lot of investigations are based on the synthesis and characterization of different metal complexes of ligands present in biological systems, or synthetic ligands, which will serve as the model molecules for complex biomolecular structures. Bio- or synthetic ligands are mainly natural chemical compounds of macromolecular type, such as carbohydrates, proteins, and nucleic acids. In this group of products very important are chemical compounds of polysaccharide dextran, pullulan and inulin with cations of the different transition biometals (Cu(II), Co(II), Zn(II) and Fe(III)). Ligands are mainly coordinated across the donor oxygen atoms used both in veterinary and human medicine, because all systems consist of the polysaccharide as energetic source, and bioelements as significant factors in metabolic processes in the organism. For prevention of anemia, products of the biological ligands and iron are usually used and there is a lot of literature data about that. Except iron, for the successful medical treatment, the presence of other hematopoietically active biometals is necessary, such as copper, cobalt and zinc. In human and veterinary medi-cine, especially interesting are products with polymicroelements, which provides the complex treatment of different diseases at the same time. This study will focus on the results of investigations carried out on the metal ion complexes of carbohydrate type ligands, with special attention to potential pharmaceutical applications of the biometal complexes with polysaccharides dextran and pullulan, and their derivatives. Acta Medica Medianae 2014;53(4):54-63.


Key words: microbial polysaccharides, dextran, pullulan, biometals, complexes