ACTA FAC. MED. NAISS. 2003; 20 (3): 151-155

Review article
 

THE USE OF ANTIBIOTICS IN RENAL FAILURE
 

Radmila Veličković, Marina Avramović, Branka Mitić, Svetislav Kostić, Sonja Radenković, Vidojko Đorđević
Institute of Nephrology and Hemodialysis, Clinical Center, Niš
 

SUMMARY
Beside excretory role in elimination of many antibiotics, there is intensive metabolism and secretion in kidney, which is essential for normal functioning of many organs and systems. The use of antibiotics in renal failure is associated with doubled risk of side and toxic effects. That is the reason why meticulously modificated dosing of antibiotics eliminating or metabolized by kidney is essential, particularly antibiotics with small therapic wideness and antibiotics which cumulate.

Key words: kidney, antibiotics, renal failure