ACTA FAC. MED. NAISS. 2003; 20 (3): 157-161

Review article
 

GENETICS OF POLYPOSIS SYNDROMES
 

Aleksandar Nagorni, Vuka Katić, Jovica Milanović, Vesna Živković, Goran Bjelaković, Biljana Radovanović-Dinić
Clinic for Gastroenterology and Hepatology and Clinic for Pathology Faculty of Medicine Nis
 

SUMMARY
Colorectal carcinoma (CRC) is one of the most common malignancies found in Western countries. The inherited gastrointestinal polyposis syndromes account for approximately 1% of all CRC cases. They can be divided into adenomatous and hamartomatous syndromes. Adenomatous polyposis syndrome is familial adenomatous polyposis (FAP) with three phenotypic variant of FAP: Gardner's syndrome, Turcot's syndrome and attenuated FAP. Hamartomatous polyposis syndromes are Peutz-Jeghers syndrome, Juvenile polyposis, Cowden's syndrome and Bannayan-Riley-Ruvalacaba syndrome.

Key words: CRC, FAP, Peuts-Jeghers syndrome, Juvenile polyposis