ACTA FAC. MED. NAISS. 2004; 21 (3): 119 - 126

     Original article

Peđa Kovačević¹, Amela Matavulj¹,Slavimir Veljković², Mirjana Čađo-Đekić³, Zvezdana Rajkovača¹, Nenad Ponorac¹

¹ Department of Physiology, School of Medicine, University of Banja Luka, Republic of Serbian;
² Institute for Physiology, School of Medicine, University of Niš; Serbia and Montenegro,
³ Clinic for Lung Diseases, Clinical Center, Banja Luka, Republic of Serbian

    Chronic renal failure is a progres sive and irreversible impairment of renal func tion. Such a con di tion dis turbs the functions of al most all organs and or gan sys tems, in clud ing lungs. In the end-stage dis ease these pa tients ex pe ri ence a spe cial form of pul mo nary oe dema called “uraemic lung”. The objective of this study was to present the effect of haemodialysis and interdialysis weight gain (water) on ventilating lung function.
    The study enrolled 32 patients with chronic renal failure that had been treated with repeated haemodialyses. The patients were separated into two groups: Group 1 – patients with interdialysis liquid gain < 5% and Group 2 – patients with interdialysis liquid intake > 5%. All the patients had body plethysmography and gas analyses done both before and after haemodialysis.
    The results obtained show that haemodialysis improves the ventilating function parameters – VC, FVC, FEV1. Dynamics of recovery of ventilating function parameters in our patients, after haemodialysis, indicates the obstructive type disorder with disfunction of small airways. Patients with greater interdialysis liquid gain have more expressive changes in ventilating function (FEV1) and poorer recovery after the dialysis.
    Different values of interdialysis gain of liquid did not have influence on haemodialysis effects on parameters of gas analyses and acid-base balance in blood.
The results lead us to a conclusion that haemodialysis has a positive effect on pulmonary ventilating function, but this effect is poorer in patients with greater interdialysis weight gain. Gas analyses and acid-base balance in blood are not reliable parameters of dyalisis (adequacy) efficacy.

    Key words: chronic renal failure, haemodialysis, respiratory function