ACTA
FAC. MED. NAISS. 2004; 21 (3): 127 - 130|
ACTA
FAC. MED. NAISS. 2004; 21 (3): 127 - 130 |
Original article
THE ROLE OF AREA POSTREMA IN THE CEN TRAL REGULATION OF ARTERIAL BLOOD PRES SURE
Rade Čukuranović1, Mirjana Radenković2, Suzana Branković2, Slavimir Veljković2
1 Institute
of Anathomy, Medical Faculty of Niš
2 Institute of Physiology, Medical Faculty of Niš
SUMMARY
Nicotine, pilocarpine and McN-A-343 (selective agonist of muscarinic M1 receptors) intracerebroventricularly in jected to cats caused a do sedepen dent de crease in arterial blood pressure. In area postrema lesioned cats, the hypotensive effect of the intracerebroventricularly in jected nicotine, pilocarpine and McN-A-343 was significantly attenuated. These au thors have found that the results obtained in the experiments sug gest that muscarinic M1 and nicotinic recep tors of the area postrema mediate in the central regulation of arterial blood pressure.
Key words: area postrema, hypotensive effect, nicotine, pilocarpine