ACTA FAC MED NAISS 2008; 25 (4): 205-210

 

Review article

 

RESISTANCE PATTERN OF INPATIENT AND OUTPATIENT ISOLATES OF PSEUDOMONAS AERUGINOSA IN THE CITY OF NIS, 2004 TO 2006 

 

Marina Dinic1,
Snezana Antic2
Branislava Kocic1
Dobrila Stankovic-Djordjevic1
Milena Bogdanovic1
Tijana Jovanovic1


 

1 Department of Microbilogy and Immunology, Faculty of Medicine, University of Nis
2 Public Health Institute Nis

 

  SUMMARY

 

Pseudomonas aeruginosa is widerspread in nature and one of the most common pathogens involved in hospital infections. The resaearch was undertaken in order to determine the current level of antibiotic susceptibility of isolates of Pseudomonas aeruginosa obtained from inpatients and outpatients and multidrug resistance. The study was carried out in the laboratory for biocultures of the Public Health Institute Nis, from November 2004 to October 2006. A total of 994 isolates of Pseudomonas aeruginosa were tested on antibiotic susceptibility using disc diffusion method, according to CLSI. These isolates were from the samples of hospitalized patients (408) and from outpatients (586). The larges number of Pseudomonas aeruginosa isolates were from surgery clinic. All isolates were tested for their sensitivity to the following antibiotics: piperacillin/tazobactam, meropenem, imipenem, ceftriaxone, ceftazidime, netilmicin, gentamicin, amikacin, ciprofloxacin, ofloxacin (Bioanalyse, Turkey between November 2004 to May 2006 and between May to October 2006 Rosco, Danmark). Susceptibility rates of outpatient isolates were higher than those from inpatient ones. Isolates showed the highest susceptibility rate to carbapenems: meropenem 87.17% and imipenem 9.25% for isolates from inpatients, meropenem 96.13% and imipenem 95.13% for isolates from outpatients. Susceptibility to piperacillin/tazobactam was 80.63% for hospital isolates and 89.83% for isolates from outpatients. The lowest susceptibility was to ceftriaxone 23.53% for hospital and 38.97% for isolates from outpatients. In our study, the multidrug resistance was in 18.14% for isolates from inpatients and 8,19% for isolates from outpatients.

Key words: Pseudomonas aeruginosa, antibiotic susceptibility, multi-drug resistance