ACTA FAC
MED NAISS 2009; 26 (2): 63-69|
ACTA FAC
MED NAISS 2009; 26 (2): 63-69 |
Original article
REVIEW OF JAW OSTEONECROSIS
IN PATIENTS TREATED WITH BISPHOSPHONATE
Milan Knezevic1, Dragan Petrovic2,
Sladjana Petrovic3
1Maxillofacial Department Hospital
University Insular, Las Palms, Spain
2 Maxillofacial Department, Faculty of
Medicine, University of Nis, Serbia
3 Institute of Radiology, Clinical Center,
Nis, Serbia
SUMMARY
This article presents a small series of the patients with osteonecrosis of the
jaws (OJ), recently treated with bisphosphonate (BP).
The OJ is a significant complication revealed recently as a consequence of the
treatment with BP.
From 2003, the cases of OJ in relation to intravenous administration of BP have
been published, particularly in the patients with advanced cancer and bone
metastases. Also, there have been mentioned the cases of OJ with oral intake of
BP.
Low incidence and lack of information as well as its recent detection results in
the fact that the OJ is still an unknown issue, although these patients are seen
relatively frequently and many patients with OJ appear in medical/dental
offices.
Key words: osteonecrosis of the jaws, bisphosphonate, osteoporosis, bone
metastases, prevention