ACTA FAC MED NAISS 2011;28(3):155-159

Rewiev article

UDC:616.24-002.7

Disease Activity Markers in Sarcoidosis

Tatjana Rađenović Petković², Tatjana Pejčić^1,2, Desa Nastasijević Borovac², Danijela Radojković^1,3, Sonja Cekić⁴

¹University of Niš, Faculty of Medicine, Serbia

²Clinic of Lung Diseases and TBC “Knez Selo”, Knez Selo, Clinical Center Niš, Serbia

³Clinic of Endocrinology and Metabolic Diseases, Clinical Center Niš, Serbia

⁴Clinic of Ophthalmology, Clinical Center Niš, Serbia


summary

Sarcoidosis is characterized by granulomatous inflammation developing in the affected organs. The ethiopathogenesis of the disease is still unknown. The lungs are most commonly affected, and uncontrolled, long-lasting inflammation can result in pulmonary fibrosis. Many different mediators, such as cytokines, chemokines, and other proteins with various functions that participate in its complex pathogenesis have been studied as markers of the disease. This article is a review of the available literature on the different markers. Although a considerable number of markers are elevated in the active stage of the disease, the studies conducted so far have shown that the values of serum ACE, IL-2R and chitotriosidase decrease with a good treatment response. KL-6 can be useful as a predictive marker for the development of pulmonary fibrosis in sarcoidosis. In conclusion, prospective studies with a larger number of patients will offer a much better insight considering the importance of these parameters when dealing with sarcoidosis.

Key words: sarcoidosis, marker, ACE