ACTA FAC MED NAISS 2018;35(2):132-139

Original article

UDC: 616.379-008.64-074

DOI: 10.2478/afmnai-2018-0015

Acid-base status of patients with diabetic ketoacidosis and ketonuria: Bosnia and Herzegovina experience

Edhem Hasković¹, Azra Bureković², Adnan Husić¹, Muhamed Fočak¹, Erna Islamagić¹

¹Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
²Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina

summary

The aim of this study was to analyze the values of biochemical parameters in patients with diabetic ketoacidosis and ketonuria.
In this prospective comparative study conducted at the Clinical Center of the University of Sarajevo, hundred patients of both genders with diabetes mellitus were enrolled. Newly diagnosed diabetic patients with complications like acute ketoacidosis (n = 50) and ketonuria (n = 50) were included in this study and compared. The values of biochemical parameters in these patients were analyzed.
We found that mean values of pH, base excess, hydrogencarbonate, sodium, glucose, urea and creatinine concentrations in patients with ketoacidosis were significantly different compared to patients with ketonuria. The values of potassium and calcium serum concentrations were not significantly different. Also, values of pH, base excess, as well as concentrations of hydrogencarbonate, sodium, potassium, calcium, glucose, urea and creatinine were not significantly different between male and female patients with diabetic ketoacidosis.
In patients with diabetic ketonuria we found a correlation between admission glucose concentration and acid-base balance.

Key words: ketoacidosis, diabetes mellitus, ketonuria