ACTA FAC MED NAISS 2020;37(4): 381-386

Original article

In Vitro Antioxidant Properties of 2-Imino-benzimidazole
and 1,3-Thiazolo[3,2-a]benzimidazolone Derivatives

Katarina Tomović¹, Jelena Mrmošanin², Denitsa Yancheva³,
Anelia Ts Mavrova⁴, Andrija Šmelcerović⁵

¹University of Niš, Faculty of Medicine, Department of Pharmacy, Niš, Serbia
²University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Serbia
³Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
⁴University of Chemical Technology and Metallurgy, Sofia, Bulgaria
⁵University of Niš, Faculty of Medicine, Department of Chemistry, Niš, Serbia

 SUMMARY

               Antioxidant properties of 2-[2-imino-5-nitro-3-(2-oxo-2-phenylethyl)-2,3-dihydro-1H-benzimidazol-1-yl]-1-phenylethanone (compound 1) and 2-(4-fluorobenzylidene)-6-(phenylcarbonyl)[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one (compound 2) were evaluated in vitro. Compounds 1 and 2 did not show significant radical scavenging activity. It has been suggested that antioxidant strategies should not be based on direct scavengers but rather on the potentiation of endogenous antioxidant defenses, or on the reduction of the sources of reactive species. Although a direct scavenging mechanism is missing, the assayed compounds (1 and 2) as evidenced inhibitors of xanthine oxidase and dipeptidyl peptidase-4 might act antioxidatively by employing other mechanisms.

Key words: 2-imino-benzimidazoles, 1,3-thiazolo[3,2-a]benzimidazolones, antioxidant activity, antioxidant mechanisms