CCL2/MCP-1 Serum Chemokine Level in Patients with Odontogenic
Infectious and Inflammatory Diseases of the Soft Tissues
 of the Maxillofacial Area and Mediastinum

 

Mariia Faustova¹, Oleksandr Nazarchuk², Dmytro Dmytriiev², David Avetikov¹,
Galina Loban’¹, Yuliana Babina², Maiia Ananieva¹

 

¹Poltava State Medical University, Poltava, Ukraine
²National Pirogov Memorial Medical University, Vinnytsia, Ukraine

 

 SUMMARY

 

Aim. The paper was aimed at determining the CCL2/MCP-1 level in patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum.

Methods. The study involved 46 patients with odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and 12 healthy volunteers. The level of patients’ plasma CCL2/MCP-1 level was determined using a kit for specific ELISA.

Results. The findings of the studies showed a statistically significant increase in the concentration of plasma CCL2/MCP-1 in patients of all study groups. Our studiy shows a significant increase in plasma CCL2/MCP-1 level in patients with odontogenic phlegmonas, abscesses and mediastinitis, compared to the group of healthy subjects.

Conclusion. CCL2/MCP-1 may play an important role in the pathogenesis of odontogenic infectious and inflammatory diseases of soft tissues of the maxillofacial area and mediastinum, which requires a careful follow-up study.

 

Keywords: odontogenic infections, chemokine, phlegmona, abscess, mediastinitis

 

 

Corresponding author:

Mariia Faustova