An Analysis of Laboratory Parameters of Chronic Kidney Failure in Elderly Patients

 

Edhem Hasković¹, Harun Uzunalıć¹, Snežana Unčanin², Safija Herenda³, Denis Hasković⁴, Amina Selimović⁵

 

¹Department of Biology, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
²Clinical Center, University of Sarajevo, Clinic of Nephrology, Sarajevo, Bosnia and Herzegovina
³Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
⁴Clinical Center, University of Sarajevo, Organizational Unit Clinical Pathology,
Cytology and Human Genetics, Sarajevo, Bosnia and Herzegovina
⁵Clinical Center, University of Sarajevo, Pediatric Clinic, Sarajevo, Bosnia and Herzegovina

 

 SUMMARY

 

Aim: The chief aim of this study was monitoring of laboratory parameters of chronic kidney failure in elderly patients.

Methods: All samples were taken and processed by standard methods and according to the principles of good laboratory practice. Data were collected in an organized and systematic manner in the form of a questionnaire with respect to ethical principles and as such were analyzed by statistical tests and analyses (Student’s t-test, Analysis of variance-ANOVA, Pearson’s and Spearman’s correlation coefficients). The limit of statistical significance was set at p < 0.05.

Results: Mean values of creatinine clearance and proteinuria for the total study population were: 41.30 ± 21.43 mL/min, 1.5 ± 2.3 g/L/24 h, respectively. Hematological parameters did not significantly differ from normal values. The highest frequency of comorbidities was observed in subjects aged ≥ 80 years with an average of 2.03 comorbidities per subject. Serum creatinine and urea values as well as creatinine clearance are good indicators of disease progression.

Conclusion: The results of the presented research suggest that old age is a predisposing risk factor for the development of chronic kidney disease, and that in combination with comorbidities (hypertension and/or diabetes), it contributes to poor prognosis or disease progression.

 

Keywords: older age, chronic kidney disease, GFR, proteinuria

 

Corresponding author:

Safija Herenda