Challenges and Gaps in the Treatment of Advanced Sleep Phase Disorder:
 A Call for Further Research and Understanding

 Dmytro I. Boiko¹, Oksana V. Mats¹, Anastasiia D. Shkodina², Andrii M. Skrypnikov¹

 ¹Department of Psychiatry, Narcology and Medical Psychology, Poltava State Medical University, Poltava, Ukraine
²Department of Neurological Diseases, Poltava State Medical University, Poltava, Ukraine

 

SUMMARY

 

People with circadian rhythm disturbances are at an elevated risk of mental disorders, and conversely, those with mental disorders are more susceptible to the circadian disruption. A steady circadian cycle of sleep and wakefulness that is phase-shifted relative to the prior local solar time may be characterized by a short endogenous circadian period. Advanced sleep-wake phase disorder (ASPD) is characterized by a substantial advancement of the sleep-wake cycle phase, followed with sleep-related symptoms. ASPD is a challenging sleep-wake disorder to manage, with current treatment options varying in efficacy and potential side effects. Further research is needed to identify effective treatment options and to elucidate the underlying mechanisms of ASPD. More research is needed to better understand the underlying mechanisms of ASPD and the molecular and metabolic changes associated with aging that may contribute to the development of the disorder.

 

Keywords: advanced sleep phase syndrome, circadian rhythm sleep disorder, sleep phase chronotherapy, melatonin, light therapy

 

Corresponding author:

Dmytro I. Boiko

e-mail: d.boiko@pdmu.edu.ua