N-Terminal Pro-Brain Natriuretic Peptide Superiority
for Prognosis of Major Adverse Cardiovascular Events
in Patients with Acute Myocardial Infarction without
Heart Failure

Rada Vučić^1,2, Vladimir Ignjatović^1,2, Olivera Andrejić³, Katarina Čupić^4,5,
Miodrag Srećković^1,2, Jelena Vučković Filipović^1,2, Marija Sekulić⁶, Milan Dobrić^7,8,
Jelena Rakočević⁹

 

¹University of Kragujevac, Faculty of Medical Sciences, Department of Internal Medicine, Kragujevac, Serbia
²University Clinical Center Kragujevac, Cardiology Clinic, Kragujevac, Serbia
³Clinical Center Kragujevac, Department of Pulmonology, Kragujevac, Serbia
⁴University of Kragujevac, Faculty of Medical Sciences, Department of Ophthalmology, Kragujevac, Serbia
⁵University Clinical Center Kragujevac, Department of Ophthalmology, Kragujevac, Serbia
⁶University of Kragujevac, Faculty of Medical Sciences, Department of Higiene and Ecology, Kragujevac, Serbia
⁷Institute for Cardiovascular Diseases “Dedinje”, Belgrade, Serbia
⁸University of Belgrade, Faculty of Medicine, Belgrade, Serbia
⁹University of Belgrade,  Faculty of Medicine, Institute of Histology and Embryology “Aleksandar Đ. Kostić“, Belgrade, Serbia

 

  SUMMARY

 

Introduction/Aim. Many markers are used to evaluate the prognosis in patients with acute myocardial infarction (AMI). Researches are focused on available markers with high sensitivity and specificity. The aim of our study was to evaluate the prognostic value of N-terminal pro brain natriuretic peptide (NT-proBNP) and its superiority compared with other prognostic markers in patients with AMI.
Patients and methods. Sixty-six patients with the diagnosis of AMI were enrolled in the study. The evaluated variables were: symptoms, cardiovascular risk factors, laboratory analyses (including NT-proBNP), GRACE risk score, electrocardiography, left ventricular ejection fraction (LVEF) and coronary angiography. One- and six-month major adverse cardiovascular events (MACE) included: reAMI, heart rhythm disorders, acute heart failure, stroke, fatal event.
Results. Patients with one-month and six-month MACE were older, had anterior AMI, higher levels of NT-proBNP, urea, creatinine, lower LVEF, creatinine clearance (CCr) and hemoglobin level. NT-proBNP is an independent predictor of short-term (p = 0.002) and long-term (p = 0.000) prognosis. Its cut point of 1,467 pg/ml is a significant independent predictor of one-month MACE and cut point of 996 pg/ml is a significant independent predictor of six-month MACE.
Conclusion. NT-proBNP is a strong short-term and long-term predictive marker in AMI patients without heart failure.

Keywords: prognosis, acute myocardial infarction, NT‒proBNP

Corresponding author:
Rada Vučić
e-mail: rada.vucic@gmail.com