Profesional work ACTA.FAC.MED.NAISS. 1999; 16(3), 163-166

P300 EVOKATED POTENTIALS AND EPILEPTIC FOCUS LATERALIZATION

Mirjana Spasić, Stojanka Djurić, Steva Lukić, Miodrag Lazarević
Klinika za neurologiju, Klinički centar, Niš

Aim: To investigate the degree of abnormality of P300 cognitive evoked potentials in patients with partial complex epilepsy and to deter-mine its predictive value in focus localization.

Investigated were 18 patients (10 women, 8 men) with an epileptic focus in their left temporal lobe (LT) and 14 (6 women and 8 men) with an epileptic focus in their left frontal lobe (LF), hospitalized at the Clinic of neurology in Niš and treated during 1997 year on outpatients basis in the Dispensary for epilepsy in Niš. The groups were homogenous re-garding age (LT 38.25 ± 9.84; LF 38 ± 8.15), disease duration (LT 16.35 ± 3.6; LF 15.9 ± 5.4), monthly frequency of attacks (LT 2.85 ± 0.79; LF 2.8 ± 0.77), QI (LT 100.75 ± 8.9, LF 97.55 ± 8.54) and education. All of the patients were right- handed. Their diagnose was made based on the clinical attacks semiology, interictal EEG findings performed in se-quence. All of the subjects had their brain CT in order. Cognitive P300 was performed in all subjects. Statistical significance was assessed with contingency coefficient and Pearson's linear correlation coefficient

Results: In LT, found was the correlation between the degree of EEG abnormality and P300 (p<0.01), while in LF group statistical sig-nificant correlation was not found. Compared to LT, cognitive P300 dem-onstrated an absolutely higher degree of abnormality (p<0.00001)

Conclusion: Cognitive evoked potentials P300 may be an addi-tional predictor of epileptic focus localization in this group of patients Key words: EEG, P300, epilepsy, epileptic focus