ACTA FAC. MED. NAISS. 2005; 22(4):175-181

   Original article

Dejan Bokonjić¹, Mirjana Mirić¹, Siniša Ristić¹, Pedja Kovačević²

¹ Department of Physiology and pathophysiology, School of Medicine University of East Sarajevo, Serbian Republic, BiH
² Department of Physiology, School of Medicine University of Banja Luka, Serbian Republic, BiH

The aim of the paper was to test the association between serum C-reactive protein (CRP) and serum ferritin and its role in the severity of anemia of hemodialysis patients. A cross-sectional study was conducted on the patients with an end-stage renal disease who underwent HD treatment with acetate basis dialysate and polysulfone membranes. There were 36 patients overall (f=15, m=21), 25 of whom were non-diabetic HD patients and 11 diabetic HD patients. There was an approximate significant inverse correlation between serum CRP and hemoglobin level and also a significant positive correlation between serum CRP and serum iron as well as an approximate significant inverse correlation between serum CRP and HD adequacy. A significant positive correlation between serum CRP and serum ferritin was registered. Malnutrition-inflammation complex syndrome may increase serum ferritin concentration apart from iron status, and needs more attention during iron therapy for the treatment of anemia in regular HD patients.

Key words: End-stage renal failure, hemodialysis, anemia, C-reactive protein, hemoglobin, hematocrit, ferritin, malnutrition-inflammation complex syndrome