ACTA FAC. MED. NAISS. 2007;24(3):165-169

 Original article

LIPID PEROXIDATION AND TOTAL SH GROUP IN PATIENTS WITH DIFFERENT FORMS OF GLOMERULONEPHRITIS

Tatjana Cvetkovic ^1,2

Branka Mitic ²

Tatjana Jevtovic ¹

Dusan Sokolovic¹

Jelena Basic¹

¹Institute of Biochemistry Faculty of Medicine in Nis

²Institute of Nephrology and Haemodialysis Clinical Centre Nis

    SUMMARY

    Reactive oxygen species (ROS) are believed to be the most important intracellular signaling molecules involved in the pathogenesis of glomerulonephritis (GN). The aim of this study was to determine the concentration of lipid peroxidation products (TBARS-thiobarbituric acid reactive substances), parameters of oxidative stress in serum and urine, as well as the concentration of serum total SH groups as one of antioxidative parameters in patients with different forms of glomerulonephritis. Our study included 42 patients treated at the Institute of Nephrology and Haemodialysis, Clinical Centre Nis. All patients with various glomerular diseases were divided into four groups: I group (n=8) comprised patients with membranous glomerulonephritis (MN).  II group (n=12)  comprised patients with  IgA nephropathy (IgA), while  III group (n=10)  recruited patients with lupus nephropathy (SLE). In the control group (IV group), there were 11 healthy subjects. The obtained results indicate that the level of TBARS in serum and urine patients with MN glomerulopathy was significantly decreased, while the concentration of total SH group was significantly increased compared to the control group. Linear correlation between TBARS as well as SH groups and creatinine clearance were established. Great importance of studying the role of oxidative stress for the onset of the illness or its complications in different forms of glomerulonephritis lies in the possibility of administration of antioxidants in the sense of therapeutic support and damage decrease.

    Key words: oxidative stress, glomerulonephritis